Grand Center Vacations from $128

Book a Hotel + Flight or Car together to unlock savings

Photo by throwingsofas

  • Plan, book, travel with confidence

  • Better together

    Save up to $2,000 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Your Grand Center Vacation

Book one of our vacation packages to Grand Center and experience the wonders of this interesting neighborhood. Especially renowned for its culture, your next awesome adventure can be found right here. Some popular nearby attractions to see during your trip to Grand Center include Busch Stadium, Gateway Arch and Dome at America’s Center. Don't just dream it — turn it into a reality! Reserve your ideal Grand Center vacation with Expedia and experience travel your way.

The Latest Grand Center Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Riverport
$128
per person
Nov 4 - Nov 6
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
7.6/10 Good! (1,012 reviews)
The Wildwood Hotel

The Wildwood Hotel

$177
per person
Nov 4 - Nov 6
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
9.2/10 Wonderful! (1,657 reviews)
Would of been great if the fire alarm didn’t malfunction at 4:30am and the ran out of breakfast items

Reviewed on Sep 25, 2026

Residence Inn by Marriott St. Louis West County

Residence Inn by Marriott St. Louis West County

Save 100% on your flight
$643
per person
Nov 4 - Nov 9
found 1 day ago
Roundtrip flight included
Philadelphia (PHL) to St. Louis (STL)
9.2/10 Wonderful! (266 reviews)
Ive stayed here before. Rooms are nice because they have a desk kitchen snd couch. Bed was not good. We stayed here because our ac went out. I called and confirmed pet friendly booked and paid for the room only to arrive and be told its $100 pet fee. Thats not fair or ok.

Reviewed on Sep 4, 2026

The Cheshire

The Cheshire

Save 100% on your flight
$369
per person
Nov 6 - Nov 9
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
8.8/10 Excellent! (1,004 reviews)
I got a room away from traffic sounds and it was great. Cute and quaint. Highly recommend to the business traveller like me.

Reviewed on Sep 25, 2026

The Principal Hotel

The Principal Hotel

Save 100% on your flight
$344
per person
Nov 5 - Nov 9
found 1 day ago
Roundtrip flight included
Minneapolis (MSP) to St. Louis (STL)
9.6/10 Exceptional! (396 reviews)

Where to stay in Grand Center

Find the best Grand Center areas and neighborhoods for the activities you enjoy most. Learn more about Grand Center
A public park with a fountain featuring bronze sculptures of mythological figures, surrounded by trees and a large building in the background.

Downtown St. Louis

4 out of top 10 points of interest in this area

Head to the heart of the largest city in Missouri for its cultural hotspots, nightlife and a colossal monument that towers over the Mississippi River.

Find hotels in Downtown St. Louis
The illuminated Gateway Arch at night with a city skyline in the background.

Clayton

1 out of top 10 points of interest in this area

Visitors often come to Clayton for its abundant dining options, but many stay to explore sights like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. Getting around the area on the metro is easy if you catch a ride at Clayton Station.

Find hotels in Clayton
A street with parked cars, a building with a sign reading "Brennan's", and a tree in front.

Central West End

Bordering Forest Park with free cultural institutions, this St. Louis neighborhood boasts a bustling commercial district along Euclid Avenue and the world's largest mosaic collection at the Cathedral Basilica of Saint Louis.

Find hotels in Central West End
A wooden bridge with metal trusses, surrounded by trees.

St. Charles Historic District

Discover a national historic district featuring over 100 buildings, including the First Missouri State Capitol and St. Charles Odd Fellows Hall, showcasing architectural styles like Greek Revival and Italianate.

Find hotels in St. Charles Historic District
A lake with a curved shoreline, a parking lot, and a forested area with autumn foliage.

Creve Coeur

Creve Coeur is known for its abundant dining options, and you can plan a trip to Creve Coeur Golf Club and Skip Viragh Center for the Arts while you're in town.

Find hotels in Creve Coeur

Grand Center Hotel Deals

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

3550 Samuel Sheppard Drive St. Louis MO
Fully refundableReserve now, pay when you stay
$118 nightly
$139 total
Oct 5 - Oct 6
Total with taxes and fees
8.8/10 Excellent! (1,160 reviews)
"Excellent roof top bar!!!"

Reviewed on Sep 24, 2026

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton
White House at Grand Central

White House at Grand Central

3805 Lindell Blvd St. Louis MO
Fully refundableReserve now, pay when you stay
$95 nightly
$146 total
Sep 27 - Sep 28
Total with taxes and fees
White House at Grand Central
Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

7750 Carondelet Avenue St. Louis MO
Fully refundableReserve now, pay when you stay
$94 nightly
$110 total
Oct 11 - Oct 12
Total with taxes and fees
8.8/10 Excellent! (3,423 reviews)
"The majority of the staff were excellent- 1 0r 2 were a bit curt or impatient at times. The majority VERY fun and helpful. However, I give some slack for the 50,000 in town for a catholic event AND another large convention. City was crazy busy with visitors. Breakfast and staff great. Rooms were ..."

Reviewed on Sep 25, 2026

Clayton Plaza Hotel & Extended Stay
See all 1,988 properties in Grand Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations
Golf Vacations
Golf Vacations
Luxury Vacations
Luxury Vacations
Romantic Vacations
Romantic Vacations
Ski Vacations
Ski Vacations
Gay Friendly Vacations
LGBTQ Friendly Vacations
LGBTQ Friendly Vacations
Adventure Vacations
Adventure Vacations
Vacations in Month
Where to go when
Where to go when
Honeymoon Vacations
Honeymoon Vacations
Mountain Vacations
Mountain Vacations
Fishing Vacations
Fishing Vacations
Adults Only Vacations
Adults Only Vacations
Waterpark Vacations
Waterpark Vacations
Scuba Diving Vacations
Scuba Diving Vacations
Yoga Vacations
Yoga Vacations
Cheap Vacations
Cheap Vacations
Solo Vacations
Solo Vacations

Stay near popular Grand Center attractions

Fox Theater

8.8/10 (417 reviews)
Enjoy an evening of comedic, dramatic and musical entertainment at this grand theater. Delve into its history on a guided tour, including behind-the-scenes details.
See properties

Powell Hall

You can make plans for a show at Powell Hall during your trip to St. Louis. Experience the area's acclaimed art scene and fascinating museums.
See properties

Powell Symphony Hall

You can make plans for a show at Powell Symphony Hall during your stay in St. Louis. Experience the area's acclaimed art scene or attend a baseball game.
See properties

Sheldon Concert Hall

You can enjoy a show at Sheldon Concert Hall during your stay in St. Louis. Experience the area's great live music or attend a baseball game.
See properties

St. Louis Symphony Orchestra

9.6/10 (9 reviews)
You can make plans for a show at St. Louis Symphony Orchestra during your stay in St. Louis. Experience the area's great live music and acclaimed art scene.
See properties

Grandel Theater

You can get tickets for a performance at Grandel Theater on your trip to St. Louis. Experience the area's acclaimed art scene or attend a baseball game.
See properties

.ZACK Theater

You can make plans for a show at .ZACK Theater during your stay in St. Louis. Experience the area's theater scene and entertainment venues.
See properties

The Sovereign - St. Louis

After visiting The Sovereign - St. Louis, make a plan to see the other sights and activities in St. Louis. Experience the area's theater scene and entertainment venues.
See properties

Things to do

St. Louis: Gateway Ghouls and Hauntings Walking Tour

St. Louis Ghost Tour: Sinister Sins & Shadows

$24
per adult
100% of travellers recommend
St. Louis Ghost Tour: Sinister Sins & Shadows
Self Guided Walking & Driving Audio Tour St. Louis

Self Guided Walk & Drive Audio Tour St. Louis & Gateway Arch NP

$15
per traveler
Self Guided Walk & Drive Audio Tour St. Louis & Gateway Arch NP
Lemp Haunted Neighborhood Walking Tour

Lemp Haunted Neighborhood Walking Tour

$25
per adult
84% of travellers recommend
Lemp Haunted Neighborhood Walking Tour
See all activities in St. Louis
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.